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pentobarbital will reduce the extent or impact of elbasvir/grazoprevir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. The therapeutic impact of elbasvir/grazoprevir could possibly be lowered if coadministered with robust CYP3A inducers and is also as a result contraindicated.fentanyl intranasal and pentobarbital each imp